The 3rd International ME/CFS Conference on May 12 and 13, 2025 in Berlin was a complete success. Organized by the Charité Fatigue Center (headed by Prof. Dr. Carmen Scheibenbogen), experts from all over the world gave lectures on aspects of pathogenesis, diagnostics and – most importantly – treatment options. The importance of the GPCR autoantibody biomarkers co-developed by CellTrend, which can be used as test kits in routine practice, was also highlighted again. There were 5000 registrations for the free online participation, including from many affected persons. In his statement on Tuesday, former Health Minister Prof. Karl Lauterbach pledged his continued support and emphasized the importance of adequate diagnosis, treatment and care of patients. This conference is to take place again next year.