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POTS/ Long Covid-diagnostics
A test panel for POTS patients is available. In addition to auto-antibodies against the Beta-1 adrenergic receptor, auto-antibodies against the Beta-2adrenergic receptor, auto-antibodies against the muscarinic cholinergic Receptor 3 (M3) and auto-antibodies against the muscarinic cholinergic Receptor 4 (M4) we will test muscarinic cholinergic Receptor 1 (M1), muscarinic cholinergic Receptor 2 (M2), muscarinic cholinergic Receptor 5 (M5), as well as Alpha-1 adrenergic receptor auto-antibodies and Alpha-2 adrenergic receptor auto-antibodies. Prof. Dr. Kem, University of Oklahoma Health Sciences Center and VA Medical Center, described the occurrence of AT1R antibodies in sera from POTS patients. Therefore, the CellTrend POTS test profile has been extended to AT1R-Ab testing. The costs for Beta-1, Beta-2 and M1-M5, ATR1 and ETAR are € 27,- ($ 33,-) each, for Alpha-1 and-2 € 112,- ($ 139,-) each and in total € 467,- ($ 575,-). It is also possible to send samples (IMPORTANT: Only send the seperated sera after centrifugation, not the entire unprocessed blood or plasma sample) for auto-antibody POTS-diagnostic to the CellTrend lab.
- Angiotensin-II-Receptor-1 (AT1R) IgG-auto-antibodies
- Endothelin-Receptor-A (ETAR) IgG-auto-antibodies
- Beta-1 adrenergic receptor auto-antibodies
- Beta-2 adrenergic receptor auto-antibodies
- Muscarinic cholinergic (M1) receptor auto-antibodies
- Muscarinic cholinergic (M2) receptor auto-antibodies
- Muscarinic cholinergic (M3) receptor auto-antibodies
- Muscarinic cholinergic (M4) receptor auto-antibodies
- Muscarinic cholinergic (M5) receptor auto-antibodies
- Alpha-1 adrenergic receptor auto-antibodies
- Alpha-2 adrenergic receptor auto-antibodies
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CFS-diagnostics
Together with Prof. Dr. Carmen Scheibenbogen, University Hospital Charite Berlin, CellTrend developed a straightforward Immuno-Assay for the diagnostic of the Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). The results have been published in Brain, Behavior, and Immunity. A first clinical trial for treatment has been successfully completed and is published in PLoS ONE (Scheibenbogen C. et al 2018).
Auto-antibodies against the Beta-2 adrenergic receptor, auto-antibodies against the muscarinic cholinergic Receptor 3 (M3) and auto-antibodies against the muscarinic cholinergic Receptor 4 (M4) are elevated in a subset of 20-30% of all patients suffering from Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). Tests are available in our lab, it is possible to send samples (IMPORTANT: Only send the seperated sera after centrifugation, not the entire unprocessed blood or plasma sample) for auto-antibody CFS-diagnostic to the CellTrend lab. The costs per biomarker are € 27,- ($ 33,-) and in total € 108,- ($ 132,-).
- Beta-1 adrenergic receptor auto-antibodies
- Beta-2 adrenergic receptor auto-antibodies
- Muscarinic cholinergic (M3) receptor auto-antibodies
- Muscarinic cholinergic (M4) receptor auto-antibodies
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Small Fiber Neuropathy (SFN)
Small Fiber Neuropathy (SFN) is a subtype of neuropathy that is characterized by the selective involvement of non-myelinated or thinly-myelinated sensory fibers is marked. Its pathogenesis includes a wide range of immune-mediated, metabolic, toxic, hereditary and genetic disorders. SFN has been described in connection with Sjögren’s syndrome, celiac disease, systemic lupus erythematosus, rheumatoid arthritis, diabetes mellitus type 1, inflammatory bowel disease, sarcoidosis and paraneoplastic syndrome. Some data also suggest an association with Hashimoto’s thyroiditis. Clinical symptoms of SFN can manifest as isolated sensory disorders as well as isolated autonomic disorders.
Intravenous immunoglobulin therapy (IVIG) showed a significant effect in treating patients with autoimmune mediated SFN in two large retrospective studies with comparable response rates (77% and 83% of patients).
Autoantibodies against fibroblast growth factor receptor-3 (FGFR3-IgG) and tri-sulfate heparin di-saccharide (TSHDS-IgM) are elevated in SFN. A clinical study is currently evaluating the efficacy of IVIG administration in FGFR3-Ab and TSHDS-Ab positive patients.
- FGFR3 auto-antibodies
- TSHDS auto-antibodies
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Important Publications
- 2016 Brain Behav Immun Scheibenbogen CFS
- 2017 Bergen – Giil – GPCR-Antibody – Heart failure
- 2017 Bergen – Giil – Ab Panel – Alzheimer
- 2018 Frontiers in Bioscience – Antibody against GPCR
- 2018 nature communications – Lübeck – Riemekasten – GPCR-Ab
- 2018 PLoS One – Berlin – Scheibenbogen – CFSME Treatment IA
- 2019 AACR- Ikeda – Matsumoto – Japan – HPV POTS
- 2019 Hum Immunol – Reinsmoen – Los Angeles – Non-HLA Antibody Transplantation
- 2019 JAHA – Gunning – Toledo – POTS
- 2019 Kidney Int – France – Lefaucheur – Kidney Transplantation AT1R-Ab
- 2020 Düsseldorf – Boege – b1-adr-R-Ab M5R-Ab – Periodontitis – aging
- 2020 Autoimmune dysautonomia – Tel-Aviv – Shoenfeld
- 2020 Brain Behaviour Immunity – Health – Uppsala – Bergquist CFS
- 2021 Journal of Autoimmunity – Israel – Shoenfeld – SBI dysautonomia
- 2021 Havard – Kruse – Autoantibodies as endogenous modulators of GPCR signaling
- 2022 Nature Communications-COVID-19
- 2023 Autoimmunity Reviews – Report of the fourth Symposium about Autoantibodies targeting G protein-coupled receptors in Lübeck
- 2023 Long COVID Symptoms