New study in Journal of American Heart Association about POTS published: Postural Orthostatic Tachycardia Syndrome Is Associated With Elevated G‐Protein Coupled Receptor Autoantibodies.
William T. GunningIII , Heather Kvale , Paula M. Kramer , Beverly L. Karabin , and Blair P. Grubb
The aim of this study was to detect both the presence and prevalence of G‐protein coupled adrenergic and cholinergic receptor antibodies in patients with postural orthostatic tachycardia syndrome. The results were surprising and unexpected because of the 55 POTS subjects evaluated, 49 (89%) were found to have elevated antibodies against the Alpha 1 adrenergic receptor and 28 subjects (51%) had elevations of antibodies against the muscarinic cholinergic receptor, M4.
The results of the study provide evidence of a potential autoimmune pathogenesis for postural orthostatic tachycardia syndrome and provide promise of establishing a standard blood test that will assist in diagnosis of postural orthostatic tachycardia Syndrome.
The figure shows patients with extremely elevated autoantibodies, some of whom with antibodies against all 9 receptor subtypes measured with CellTrend ELISA Kits.
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