Human papillomavirus (HPV) infection promotes uterine and cervical cancers. In 2010, HPV vaccines were introduced worldwide. Since then case series of suspected adverse effects after HPV vaccination have been reported from several countries and the symptoms described by independent researchers are similar.

In this study, autoantibodies against diverse Gprotein coupled receptors in the serum of japanese girls who complained of possible adverse effects after HPV vaccination were investigated. Fifty five girls with HPV vaccination and 57 girls without HPV immunization were enrolled. The serum levels of autoantibodies against the adrenergic receptors α1, α2, β1and β2, muscarinic acetylcholine receptors 1, 2, 3, 4, 5; and endothelin receptor A was significantly elevated in girls with HPV vaccination, compared with those in the controls.

Is there a causal link between HPV vaccination and POTS or CRPS?


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