The article about autoantibodies targeting GPCRs and RAS-related molecules associate with COVID-19 severity is published. In this new study of 246 individuals the IgG autoantibodies against 14 different GPCRs were detected with CellTrend kits. The production of these autoantibodies is deregulated in COVID-19. Patients with moderate and severe disease have higher levels of autoantibodies than the healthy controls. Follow-up analysis indicated that CXCR3-aab, MAS1-aab, AGTR1-aab, CHRM5-aab and BDKRB1-aab were the five most significant predictors of COVID-19 disease-severity.
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