CFS-diagnostics

Together with Prof. Dr. Carmen Scheibenbogen, University Hospital Charite Berlin, CellTrend developed a straightforward Immuno-Assay for the diagnostic  of the Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). The results have been published in Brain, Behavior, and Immunity.  A first clinical trial for treatment has been successfully completed and is published in PLoS ONE (Scheibenbogen C. et al 2018). 

Auto-antibodies against the Beta-2 adrenergic receptor, auto-antibodies against the muscarinic cholinergic Receptor 3 (M3) and auto-antibodies against the muscarinic cholinergic Receptor 4 (M4) are elevated in a subset of 20-30% of all patients suffering from Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). Tests are available in our lab, it is possible to send samples (IMPORTANT: Only send the seperated sera after centrifugation, not the entire unprocessed blood or plasma sample) for auto-antibody CFS-diagnostic to the CellTrend lab. The costs per biomarker are € 27,- ($ 33,-) and in total € 108,- ($ 132,-).

  • Beta-1 adrenergic receptor auto-antibodies 
  • Beta-2 adrenergic receptor auto-antibodies 
  • Muscarinic cholinergic (M3) receptor auto-antibodies ELISA 
  • Muscarinic cholinergic (M4) receptor auto-antibodies ELISA 

POTS-diagnostics

Also available is a test panel for POTS patients. In addition to auto-antibodies against the Beta-1 adrenergic receptor, auto-antibodies against the Beta-2adrenergic receptor, auto-antibodies against the muscarinic cholinergic Receptor 3 (M3) and auto-antibodies against the muscarinic cholinergic Receptor 4 (M4) we will test muscarinic cholinergic Receptor 1 (M1), muscarinic cholinergic Receptor 2 (M2), muscarinic cholinergic Receptor 5 (M5), as well as Alpha-1 adrenergic receptor auto-antibodies and Alpha-2 adrenergic receptor auto-antibodies. Prof. Dr. Kem, University of Oklahoma Health Sciences Center and VA Medical Center, described the occurrence of AT1R antibodies in sera from POTS patients. Therefore, the CellTrend POTS test profile has been extended to AT1R-Ab testing. The costs for Beta-1, Beta-2 and M1-M5, ATR1 and ETAR are € 27,- ($ 33,-) each, for Alpha-1 and-2 € 112,- ($ 139,-) each and in total € 467,- ($ 575,-). It is also possible to send samples (IMPORTANT: Only send the seperated sera after centrifugation, not the entire unprocessed blood or plasma sample) for auto-antibody POTS-diagnostic to the CellTrend lab.

  • Angiotensin-II-Receptor-1 (AT1R) IgG-auto-antibodies
  • Endothelin-Receptor-A (ETAR) IgG-auto-antibodies
  • Beta-1 adrenergic receptor auto-antibodies 
  • Beta-2 adrenergic receptor auto-antibodies 
  • Muscarinic cholinergic (M1) receptor auto-antibodies  
  • Muscarinic cholinergic (M2) receptor auto-antibodies
  • Muscarinic cholinergic (M3) receptor auto-antibodies
  • Muscarinic cholinergic (M4) receptor auto-antibodies
  • Muscarinic cholinergic (M5) receptor auto-antibodies 
  • Alpha-1 adrenergic receptor auto-antibodies
  • Alpha-2 adrenergic receptor auto-antibodies